Ribosomal mutations in Arcanobacterium pyogenes confer a unique spectrum of macrolide resistance.
نویسندگان
چکیده
Four macrolide-resistant Arcanobacterium pyogenes isolates contained A2058T, A2058G, or C2611G (Escherichia coli numbering) mutations in their 23S rRNA genes. While these mutations conferred resistance to erythromycin, oleandomycin, and spiramycin, they did not confer resistance to tylosin.
منابع مشابه
Resistance to macrolides in clinical isolates of Streptococcus pyogenes due to ribosomal mutations.
OBJECTIVE Two clinical strains of Streptococcus pyogenes, 237 and 544, one isolated in Slovakia and the other in Croatia, that were resistant to azithromycin (MIC 8 and 2 mg/L, respectively) but susceptible to erythromycin (MIC 0.5 and 0.12 mg/L, respectively) did not contain any gene known to confer macrolide resistance by ribosomal modification (erm gene) or efflux [mef(A) and msr(A) genes]. ...
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ورودعنوان ژورنال:
- Antimicrobial agents and chemotherapy
دوره 48 3 شماره
صفحات -
تاریخ انتشار 2004